![]() ![]() Biological age can represent a person’s aging status more appropriately compared to chronological age because, while chronological age is just a period of living which does not consider person’s health status, biological age is associated with health status, which is closely related with aging. Many studies have been conducted to quantitatively estimate biological age using measurable biomarkers since a study by Comfort in 1969. Conclusionsīiological age could be used to predict future risk of death, and its effect size varied according to gender, chronological age, and cause of death. The survival probability, over the 17 year term of the study, was significantly decreased in the people whose biological age was larger than chronological age (log rank test, p value < 0.001). The largest hazard ratio was observed in subjects whose baseline chronological age was within 50–59 years when the cause was death from non-cancerous diseases (HR = 1.30, 95% confidence intervals = 1.26 - 1.34). The death rate significantly increased as biological age became larger than chronological age (linear trend test, p value < 0.0001). In the deceased, the biological age was larger than the chronological age: largest increment of biological age over chronological age was observed when their baseline chronological age was within 50–59 years. In the living subjects, the average biological age was almost the same as the average chronological age. The influence of biological age on future mortality was analyzed using Cox proportional hazards regression considering gender, chronological age, and event type. Biological ages were computed using 15 biomarkers measured in general health check-ups using an algorithm based on principal component analysis. The data consists of 13,106 cases of death from 557,940 Koreans at 20–93 years old, surveyed from 1994 to 2011. The purpose of this study is to demonstrate the validity of biological age as a useful index to predict a person’s risk of death in the future. A validation study using cohort data found biological age to be a superior index for disease-related mortality than chronological age. ![]() Biological age should function as a valid proxy for aging, which is closely related with future work ability, frailty, physical fitness, and/or mortality. ![]() Many studies have been conducted to quantitatively estimate biological age using measurable biomarkers. ![]()
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